Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

BACKGROUND: Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in humans remains poorly understood. While DNA methylation at many CpG sites closely tracks chronological age, DNA methylation changes relevant to biological age are expected to gradually dissociate from chronolo...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Slieker, Roderick C., van Iterson, Maarten, Luijk, René, Beekman, Marian, Zhernakova, Daria V., Moed, Matthijs H., Mei, Hailiang, van Galen, Michiel, Deelen, Patrick, Bonder, Marc Jan, Zhernakova, Alexandra, Uitterlinden, André G., Tigchelaar, Ettje F., Stehouwer, Coen D. A., Schalkwijk, Casper G., van der Kallen, Carla J. H., Hofman, Albert, van Heemst, Diana, de Geus, Eco J., van Dongen, Jenny, Deelen, Joris, van den Berg, Leonard H., van Meurs, Joyce, Jansen, Rick, ‘t Hoen, Peter A. C., Franke, Lude, Wijmenga, Cisca, Veldink, Jan H., Swertz, Morris A., van Greevenbroek, Marleen M. J., van Duijn, Cornelia M., Boomsma, Dorret I., Slagboom, P. Eline, Heijmans, Bastiaan T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032245/
https://ncbi.nlm.nih.gov/pubmed/27654999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1053-6
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