Blood lipids influence DNA methylation in circulating cells

BACKGROUND: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the development of atherosclerosis. To...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Biol
Prif Awduron: Dekkers, Koen F., van Iterson, Maarten, Slieker, Roderick C., Moed, Matthijs H., Bonder, Marc Jan, van Galen, Michiel, Mei, Hailiang, Zhernakova, Daria V., van den Berg, Leonard H., Deelen, Joris, van Dongen, Jenny, van Heemst, Diana, Hofman, Albert, Hottenga, Jouke J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Stehouwer, Coen D. A., Tigchelaar, Ettje F., Uitterlinden, André G., Willemsen, Gonneke, Zhernakova, Alexandra, Franke, Lude, ’t Hoen, Peter A. C., Jansen, Rick, van Meurs, Joyce, Boomsma, Dorret I., van Duijn, Cornelia M., van Greevenbroek, Marleen M. J., Veldink, Jan H., Wijmenga, Cisca, van Zwet, Erik W., Slagboom, P. Eline, Jukema, J. Wouter, Heijmans, Bastiaan T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922056/
https://ncbi.nlm.nih.gov/pubmed/27350042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1000-6
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