Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

Following the discovery of BRD4 as a non-oncogene addiction target in acute myeloid leukemia (AML)1,2, BET inhibitors are being explored as promising therapeutic avenue in numerous cancers3–5. While clinical trials have reported single-agent activity in advanced hematologic malignancies6, mechanisms...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Rathert, Philipp, Roth, Mareike, Neumann, Tobias, Muerdter, Felix, Roe, Jae-Seok, Muhar, Matthias, Deswal, Sumit, Cerny-Reiterer, Sabine, Peter, Barbara, Jude, Julian, Hoffmann, Thomas, Boryń, Łukasz M., Axelsson, Elin, Schweifer, Norbert, Tontsch-Grunt, Ulrike, Dow, Lukas E., Gianni, Davide, Pearson, Mark, Valent, Peter, Stark, Alexander, Kraut, Norbert, Vakoc, Christopher R., Zuber, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921058/
https://ncbi.nlm.nih.gov/pubmed/26367798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14898
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