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Regulation of NO Synthesis, Local Inflammation, and Innate Immunity to Pathogens by BET Family Proteins

Transcriptional activation of the Nos2 gene, encoding inducible nitric oxide synthase (iNOS), during infection or inflammation requires coordinate assembly of an initiation complex by the transcription factors NF-κB and type I interferon-activated ISGF3. Here we show that infection of macrophages wi...

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Detalhes bibliográficos
Main Authors: Wienerroither, Sebastian, Rauch, Isabella, Rosebrock, Felix, Jamieson, Amanda M., Bradner, James, Muhar, Matthias, Zuber, Johannes, Müller, Mathias, Decker, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911514/
https://ncbi.nlm.nih.gov/pubmed/24248598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01353-13
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