High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva

The ACVR1 gene encodes a type I receptor of bone morphogenetic proteins (BMPs). Activating mutations in ACVR1 are responsible for fibrodysplasia ossificans progressiva (FOP), a rare disease characterized by congenital toe malformation and progressive heterotopic endochondral ossification leading to...

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Detalles Bibliográficos
Publicado en:Dis Model Mech
Main Authors: Cappato, Serena, Tonachini, Laura, Giacopelli, Francesca, Tirone, Mario, Galietta, Luis J. V., Sormani, Martina, Giovenzana, Anna, Spinelli, Antonello E., Canciani, Barbara, Brunelli, Silvia, Ravazzolo, Roberto, Bocciardi, Renata
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920148/
https://ncbi.nlm.nih.gov/pubmed/27125279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.023929
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