Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

[Image: see text] Bromodomain containing proteins PB1, SMARCA4, and SMARCA2 are important components of SWI/SNF chromatin remodeling complexes. We identified bromodomain inhibitors that target these proteins and display unusual binding modes involving water displacement from the KAc binding site. Th...

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Vydáno v:J Med Chem
Hlavní autoři: Sutherell, Charlotte L., Tallant, Cynthia, Monteiro, Octovia P., Yapp, Clarence, Fuchs, Julian E., Fedorov, Oleg, Siejka, Paulina, Müller, Suzanne, Knapp, Stefan, Brenton, James D., Brennan, Paul E., Ley, Steven V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2016
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920105/
https://ncbi.nlm.nih.gov/pubmed/27119626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01997
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