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Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver

Accumulation of sterols in endoplasmic reticulum membranes stimulates the ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which catalyzes a rate-limiting step in synthesis of cholesterol. This ubiquitination marks HMGCR for proteasome-mediated degradation and constitutes o...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Hwang, Seonghwan, Hartman, Isamu Z., Calhoun, Leona N., Garland, Kristina, Young, Gennipher A., Mitsche, Matthew A., McDonald, Jeffrey, Xu, Fang, Engelking, Luke, DeBose-Boyd, Russell A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919435/
https://ncbi.nlm.nih.gov/pubmed/27129778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.728469
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