Insig-mediated, Sterol-accelerated Degradation of the Membrane Domain of Hamster 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase in Insect Cells

Sterol-accelerated degradation of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase is one of several mechanisms through which cholesterol synthesis is controlled in mammalian cells. This degradation results from sterol-induced binding of the membrane domain of reductase to endoplasmic reti...

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Detalhes bibliográficos
Main Authors: Nguyen, Andrew D., Lee, Soo Hee, DeBose-Boyd, Russell A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785366/
https://ncbi.nlm.nih.gov/pubmed/19638338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032342
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