Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets

Sterol-induced binding to Insigs in the endoplasmic reticulum (ER) allows for ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. This ubiquitination marks reductase for recognition by the ATPase VCP/p97, which mediates extraction and...

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Bibliographische Detailangaben
Hauptverfasser: Hartman, Isamu Z., Liu, Pingsheng, Zehmer, John K., Luby-Phelps, Katherine, Jo, Youngah, Anderson, Richard G. W., DeBose-Boyd, Russell A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885207/
https://ncbi.nlm.nih.gov/pubmed/20406816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134213
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