Sequential Actions of the AAA-ATPase Valosin-containing Protein (VCP)/p97 and the Proteasome 19 S Regulatory Particle in Sterol-accelerated, Endoplasmic Reticulum (ER)-associated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

Accelerated endoplasmic reticulum (ER)-associated degradation (ERAD) of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase results from its sterol-induced binding to ER membrane proteins called Insig-1 and Insig-2. This binding allows for subsequent ubiquitination of...

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Detalles Bibliográficos
Autores principales: Morris, Lindsey L., Hartman, Isamu Z., Jun, Dong-Jae, Seemann, Joachim, DeBose-Boyd, Russell A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081943/
https://ncbi.nlm.nih.gov/pubmed/24860107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.576652
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