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Introduction of a polar core into the de novo designed protein Top7
Design of polar interactions is a current challenge for protein design. The de novo designed protein Top7, like almost all designed proteins, has an entirely nonpolar core. Here we describe the replacing of a sizable fraction (5 residues) of this core with a designed polar hydrogen bond network. The...
שמור ב:
| הוצא לאור ב: | Protein Sci |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
John Wiley and Sons Inc.
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4918430/ https://ncbi.nlm.nih.gov/pubmed/26873166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2899 |
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