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De novo prediction of protein folding pathways and structure using the principle of sequential stabilization

Motivated by the relationship between the folding mechanism and the native structure, we develop a unified approach for predicting folding pathways and tertiary structure using only the primary sequence as input. Simulations begin from a realistic unfolded state devoid of secondary structure and use...

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Библиографические подробности
Главные авторы: Adhikari, Aashish N., Freed, Karl F., Sosnick, Tobin R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491489/
https://ncbi.nlm.nih.gov/pubmed/23045636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209000109
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