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Simplified protein models can rival all atom simulations in predicting folding pathways and structure

We demonstrate the ability of simultaneously determining a protein’s folding pathway and structure using a properly formulated model without prior knowledge of the native structure. Our model employs a natural coordinate system for describing proteins and a search strategy inspired by the observatio...

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Bibliographic Details
Main Authors: Adhikari, Aashish N., Freed, Karl F., Sosnick, Tobin R.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047675/
https://ncbi.nlm.nih.gov/pubmed/23889448
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