Introduction of a polar core into the de novo designed protein Top7

Design of polar interactions is a current challenge for protein design. The de novo designed protein Top7, like almost all designed proteins, has an entirely nonpolar core. Here we describe the replacing of a sizable fraction (5 residues) of this core with a designed polar hydrogen bond network. The...

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Bibliografski detalji
Izdano u:Protein Sci
Glavni autori: Basanta, Benjamin, Chan, Kui K., Barth, Patrick, King, Tiffany, Sosnick, Tobin R., Hinshaw, James R., Liu, Gaohua, Everett, John K., Xiao, Rong, Montelione, Gaetano T., Baker, David
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918430/
https://ncbi.nlm.nih.gov/pubmed/26873166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2899
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