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Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases
Lactate and malate dehydrogenases (LDH and MDH) are homologous, core metabolic enzymes common to nearly all living organisms. LDHs have evolved convergently from MDHs at least four times, achieving altered substrate specificity by a different mechanism each time. For instance, the LDH of anaerobic t...
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| Udgivet i: | Protein Sci |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4918429/ https://ncbi.nlm.nih.gov/pubmed/26889885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2904 |
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