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An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases
Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for their substrates. In the Apicomplexa, convergent evolution of an unusual LDH from MDH produced a difference in specificity exceeding 12...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109310/ https://ncbi.nlm.nih.gov/pubmed/24966208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02304 |
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