p53 Localization at Centrosomes during Mitosis and Postmitotic Checkpoint Are ATM-dependent and Require Serine 15 Phosphorylation

We recently demonstrated that the p53 oncosuppressor associates to centrosomes in mitosis and this association is disrupted by treatments with microtubule-depolymerizing agents. Here, we show that ATM, an upstream activator of p53 after DNA damage, is essential for p53 centrosomal localization and i...

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Bibliografiske detaljer
Main Authors: Tritarelli, A., Oricchio, E., Ciciarello, M., Mangiacasale, R., Palena, A., Lavia, P., Soddu, S., Cundari, E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2004
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC491834/
https://ncbi.nlm.nih.gov/pubmed/15181149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-12-0900
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