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TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

Upon prolonged arrest in mitosis, cells undergo adaptation and exit mitosis without cell division. These tetraploid cells are either eliminated by apoptosis or arrested in the subsequent G(1) phase in a spindle checkpoint- and p53-dependent manner. p53 has long been known to be activated by spindle...

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Bibliografski detalji
Glavni autori: Huang, Yi-Fu, Chang, Margaret Dah-Tsyr, Shieh, Sheau-Yann
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682006/
https://ncbi.nlm.nih.gov/pubmed/19332559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01837-08
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