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TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

Upon prolonged arrest in mitosis, cells undergo adaptation and exit mitosis without cell division. These tetraploid cells are either eliminated by apoptosis or arrested in the subsequent G(1) phase in a spindle checkpoint- and p53-dependent manner. p53 has long been known to be activated by spindle...

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Detalhes bibliográficos
Main Authors: Huang, Yi-Fu, Chang, Margaret Dah-Tsyr, Shieh, Sheau-Yann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682006/
https://ncbi.nlm.nih.gov/pubmed/19332559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01837-08
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