Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required For Mitotic ATM Activation and the Spindle Checkpoint

The ATM kinase plays a critical role in the maintenance of genetic stability. ATM is activated in response to DNA damage and is essential for cell cycle checkpoints. Here, we report that ATM is activated in mitosis in the absence of DNA damage. We demonstrate that mitotic ATM activation is dependent...

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Библиографические подробности
Главные авторы: Yang, Chunying, Tang, Xi, Guo, Xiaojing, Niikura, Yohei, Kitagawa, Katsumi, Cui, Kemi, Wong, Stephen T.C., Fu, Li, Xu, Bo
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228519/
https://ncbi.nlm.nih.gov/pubmed/22099307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.09.016
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