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Aurora Kinases Phosphorylate Lgl to Induce Mitotic Spindle Orientation in Drosophila Epithelia

The Lethal giant larvae (Lgl) protein was discovered in Drosophila as a tumor suppressor in both neural stem cells (neuroblasts) and epithelia. In neuroblasts, Lgl relocalizes to the cytoplasm at mitosis, an event attributed to phosphorylation by mitotically activated aPKC kinase and thought to prom...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Curr Biol
Prif Awduron: Bell, Graham P., Fletcher, Georgina C., Brain, Ruth, Thompson, Barry J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291145/
https://ncbi.nlm.nih.gov/pubmed/25484300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.10.052
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