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Aurora Kinases Phosphorylate Lgl to Induce Mitotic Spindle Orientation in Drosophila Epithelia

The Lethal giant larvae (Lgl) protein was discovered in Drosophila as a tumor suppressor in both neural stem cells (neuroblasts) and epithelia. In neuroblasts, Lgl relocalizes to the cytoplasm at mitosis, an event attributed to phosphorylation by mitotically activated aPKC kinase and thought to prom...

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Pubblicato in:Curr Biol
Autori principali: Bell, Graham P., Fletcher, Georgina C., Brain, Ruth, Thompson, Barry J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291145/
https://ncbi.nlm.nih.gov/pubmed/25484300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.10.052
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