Aurora Kinases Phosphorylate Lgl to Induce Mitotic Spindle Orientation in Drosophila Epithelia

The Lethal giant larvae (Lgl) protein was discovered in Drosophila as a tumor suppressor in both neural stem cells (neuroblasts) and epithelia. In neuroblasts, Lgl relocalizes to the cytoplasm at mitosis, an event attributed to phosphorylation by mitotically activated aPKC kinase and thought to prom...

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Detaylı Bibliyografya
Yayımlandı:Curr Biol
Asıl Yazarlar: Bell, Graham P., Fletcher, Georgina C., Brain, Ruth, Thompson, Barry J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2015
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291145/
https://ncbi.nlm.nih.gov/pubmed/25484300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.10.052
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