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Aurora Kinases Phosphorylate Lgl to Induce Mitotic Spindle Orientation in Drosophila Epithelia

The Lethal giant larvae (Lgl) protein was discovered in Drosophila as a tumor suppressor in both neural stem cells (neuroblasts) and epithelia. In neuroblasts, Lgl relocalizes to the cytoplasm at mitosis, an event attributed to phosphorylation by mitotically activated aPKC kinase and thought to prom...

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Publicado en:Curr Biol
Autores principales: Bell, Graham P., Fletcher, Georgina C., Brain, Ruth, Thompson, Barry J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291145/
https://ncbi.nlm.nih.gov/pubmed/25484300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.10.052
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