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Mechanisms of interstrand DNA crosslink repair and human disorders

Interstrand DNA crosslinks (ICLs) are the link between Watson-Crick strands of DNAs with the covalent bond and prevent separation of DNA strands. Since the ICL lesion affects both strands of the DNA, the ICL repair is not simple. So far, nucleotide excision repair (NER), structure-specific endonucle...

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Bibliografiske detaljer
Udgivet i:Genes Environ
Main Authors: Hashimoto, Satoru, Anai, Hirofumi, Hanada, Katsuhiro
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918140/
https://ncbi.nlm.nih.gov/pubmed/27350828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-016-0037-9
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