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Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer

Colorectal cancer (CRC) displays a complex pattern of inheritance. It is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. In this study, we assay the impact of rare germline mutations on CRC, analysi...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Commun
Main Authors: Chubb, Daniel, Broderick, Peter, Dobbins, Sara E., Frampton, Matthew, Kinnersley, Ben, Penegar, Steven, Price, Amy, Ma, Yussanne P., Sherborne, Amy L., Palles, Claire, Timofeeva, Maria N., Bishop, D. Timothy, Dunlop, Malcolm G., Tomlinson, Ian, Houlston, Richard S.
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917884/
https://ncbi.nlm.nih.gov/pubmed/27329137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11883
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