Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer

Colorectal cancer (CRC) displays a complex pattern of inheritance. It is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. In this study, we assay the impact of rare germline mutations on CRC, analysi...

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書誌詳細
出版年:Nat Commun
主要な著者: Chubb, Daniel, Broderick, Peter, Dobbins, Sara E., Frampton, Matthew, Kinnersley, Ben, Penegar, Steven, Price, Amy, Ma, Yussanne P., Sherborne, Amy L., Palles, Claire, Timofeeva, Maria N., Bishop, D. Timothy, Dunlop, Malcolm G., Tomlinson, Ian, Houlston, Richard S.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917884/
https://ncbi.nlm.nih.gov/pubmed/27329137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11883
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