Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti‐hyperalgesic effects, in patients with sciatica

AIMS: BG00010 is a protein in the glial cell line‐derived neurotrophic factor (GDNF) family. It is a selective ligand for the GDNF family receptor alpha‐3 (GFRα3) co‐receptor that normalizes cellular changes resulting from damage or disease, and potentially alleviates neuropathic pain. The main obje...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Okkerse, Pieter, Hay, Justin L., Versage, Eve, Tang, Yongqiang, Galluppi, Gerald, Ravina, Bernard, Verma, Ajay, Williams, Leslie, Aycardi, Ernesto, Groeneveld, Geert Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Pharmacokinetic Dynamic Relationships
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917813/
https://ncbi.nlm.nih.gov/pubmed/27016000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12941
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