First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica

OBJECTIVE: To evaluate the safety, tolerability, and pharmacokinetics of single doses of BG00010 (neublastin, artemin, enovin) in subjects with unilateral sciatica. METHODS: This was a single-center, blinded, placebo-controlled, randomized Phase 1 sequential-cohort, dose-escalation study (ClinicalTr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rolan, Paul E., O’Neill, Gilmore, Versage, Eve, Rana, Jitesh, Tang, Yongqiang, Galluppi, Gerald, Aycardi, Ernesto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427304/
https://ncbi.nlm.nih.gov/pubmed/25962165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125034
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