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Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties

AIM: Xen2174 is a synthetic 13‐amino acid peptide that binds specifically to the norepinephrine transporter, which results in inhibition of norepinephrine uptake. It is being developed as a possible treatment for moderate to severe pain and is delivered intrathecally. The current study was performed...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Okkerse, Pieter, Hay, Justin L., Sitsen, Elske, Dahan, Albert, Klaassen, Erica, Houghton, William, Groeneveld, Geert Jan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346871/
https://ncbi.nlm.nih.gov/pubmed/27987228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13176
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