'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'

Friedreich's ataxia (FRDA) is an inherited neurodegenerative disease. The mutation consists of a GAA repeat expansion within the FXN gene, which downregulates frataxin, leading to abnormal mitochondrial iron accumulation, which may in turn cause changes in mitochondrial function. Although, many...

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Publicat a:Cell Death Dis
Autors principals: Abeti, R, Parkinson, M H, Hargreaves, I P, Angelova, P R, Sandi, C, Pook, M A, Giunti, P, Abramov, A Y
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917650/
https://ncbi.nlm.nih.gov/pubmed/27228352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.111
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