Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-γ

Persistent or dysregulated IL-13 responses are key drivers of fibrosis in multiple organ systems, and this identifies this cytokine as an important therapeutic target. Nevertheless, the mechanisms by which IL-13 blockade leads to the amelioration of fibrosis remain unclear. Because IFN-γ exhibits po...

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Pubblicato in:J Pathol
Autori principali: Ramalingam, Thirumalai R, Gieseck, Richard L., Acciani, Thomas H., Hart, Kevin M., Cheever, Allen W., Mentink-Kane, Margaret M., Vannella, Kevin M., Wynn, Thomas A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915976/
https://ncbi.nlm.nih.gov/pubmed/27125685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4733
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