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Loss of presenilin function is associated with a selective gain of APP function
Presenilin 1 (PS1) is an essential γ-secretase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavage. Mutations in PS1 lead to dominant-inheritance of early-onset familial Alzheimer’s disease (FAD). Although expression of FAD-linked PS1 mutations enhances to...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4915812/ https://ncbi.nlm.nih.gov/pubmed/27196744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15645 |
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