Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity

In order for a virus to persist, there must be a balance between viral replication and immune clearance. It is commonly believed that adaptive immunity drives clearance of viral infections and, thus, dysfunction or viral evasion of adaptive immunity is required for a virus to persist. Type I interfe...

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Publicat a:PLoS Pathog
Autors principals: Nice, Timothy J., Osborne, Lisa C., Tomov, Vesselin T., Artis, David, Wherry, E. John, Virgin, Herbert W.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915689/
https://ncbi.nlm.nih.gov/pubmed/27327515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005684
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