Differentiation and protective capacity of virus-specific CD8(+) T cells suggest murine norovirus persistence in an immune-privileged enteric niche

Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown. We used genetically engineered strains of mouse norovirus (MNV) to investigate CD8(+) T cell differentiation during chronic inf...

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Publicado en:Immunity
Autores principales: Tomov, Vesselin T., Palko, Olesya, Lau, Chi Wai, Pattekar, Ajinkya, Sun, Yuhang, Tacheva, Ralitza, Bengsch, Bertram, Manne, Sasikanth, Cosma, Gabriela L., Eisenlohr, Laurence, Nice, Timothy J., Virgin, Herbert W., Wherry, E. John
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077984/
https://ncbi.nlm.nih.gov/pubmed/29031786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.09.017
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