Differentiation and protective capacity of virus-specific CD8(+) T cells suggest murine norovirus persistence in an immune-privileged enteric niche

Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown. We used genetically engineered strains of mouse norovirus (MNV) to investigate CD8(+) T cell differentiation during chronic inf...

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Bibliografiset tiedot
Julkaisussa:Immunity
Päätekijät: Tomov, Vesselin T., Palko, Olesya, Lau, Chi Wai, Pattekar, Ajinkya, Sun, Yuhang, Tacheva, Ralitza, Bengsch, Bertram, Manne, Sasikanth, Cosma, Gabriela L., Eisenlohr, Laurence, Nice, Timothy J., Virgin, Herbert W., Wherry, E. John
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077984/
https://ncbi.nlm.nih.gov/pubmed/29031786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.09.017
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