Pannexin-1 and P2X7-receptor are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes

Osteocyte apoptosis is required to induce intracortical bone remodeling following microdamage in animal models, but how apoptotic osteocytes signal neighboring “bystander” cells to initiate the remodeling process is unknown. Apoptosis has been shown to open pannexin-1 (Panx1) channels to release ATP...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Bone Miner Res
Autori principali: Cheung, Wing Yee, Fritton, J. Christopher, Morgan, StacyAnn, Seref-Ferlengez, Zeynep, Basta-Pljakic, Jelena, Thi, Mia M., Suadicani, Sylvia O., Spray, David C., Majeska, Robert J., Schaffler, Mitchell B
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915221/
https://ncbi.nlm.nih.gov/pubmed/26553756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2740
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi