Pannexin-1 and P2X7-receptor are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes

Osteocyte apoptosis is required to induce intracortical bone remodeling following microdamage in animal models, but how apoptotic osteocytes signal neighboring “bystander” cells to initiate the remodeling process is unknown. Apoptosis has been shown to open pannexin-1 (Panx1) channels to release ATP...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Bone Miner Res
Hauptverfasser: Cheung, Wing Yee, Fritton, J. Christopher, Morgan, StacyAnn, Seref-Ferlengez, Zeynep, Basta-Pljakic, Jelena, Thi, Mia M., Suadicani, Sylvia O., Spray, David C., Majeska, Robert J., Schaffler, Mitchell B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915221/
https://ncbi.nlm.nih.gov/pubmed/26553756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2740
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge