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Pannexin-1 and P2X7-receptor are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes

Osteocyte apoptosis is required to induce intracortical bone remodeling following microdamage in animal models, but how apoptotic osteocytes signal neighboring “bystander” cells to initiate the remodeling process is unknown. Apoptosis has been shown to open pannexin-1 (Panx1) channels to release ATP...

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Publicat a:J Bone Miner Res
Autors principals: Cheung, Wing Yee, Fritton, J. Christopher, Morgan, StacyAnn, Seref-Ferlengez, Zeynep, Basta-Pljakic, Jelena, Thi, Mia M., Suadicani, Sylvia O., Spray, David C., Majeska, Robert J., Schaffler, Mitchell B
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915221/
https://ncbi.nlm.nih.gov/pubmed/26553756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2740
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