Pannexin-1 and P2X7-receptor are required for apoptotic osteocytes in fatigued bone to trigger RANKL production in neighboring bystander osteocytes

Osteocyte apoptosis is required to induce intracortical bone remodeling following microdamage in animal models, but how apoptotic osteocytes signal neighboring “bystander” cells to initiate the remodeling process is unknown. Apoptosis has been shown to open pannexin-1 (Panx1) channels to release ATP...

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Gepubliceerd in:J Bone Miner Res
Hoofdauteurs: Cheung, Wing Yee, Fritton, J. Christopher, Morgan, StacyAnn, Seref-Ferlengez, Zeynep, Basta-Pljakic, Jelena, Thi, Mia M., Suadicani, Sylvia O., Spray, David C., Majeska, Robert J., Schaffler, Mitchell B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915221/
https://ncbi.nlm.nih.gov/pubmed/26553756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2740
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