Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression

Death-associated protein kinase (DAPK) is a tumour suppressor. Here we show that DAPK also inhibits T helper 17 (Th17) and prevents Th17-mediated pathology in a mouse model of autoimmunity. We demonstrate that DAPK specifically downregulates hypoxia-inducible factor 1α (HIF-1α). In contrast to the p...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Chou, Ting-Fang, Chuang, Ya-Ting, Hsieh, Wan-Chen, Chang, Pei-Yun, Liu, Hsin-Yu, Mo, Shu-Ting, Hsu, Tzu-Sheng, Miaw, Shi-Chuen, Chen, Ruey-Hwa, Kimchi, Adi, Lai, Ming-Zong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915028/
https://ncbi.nlm.nih.gov/pubmed/27312851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11904
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