WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila

WD40 proteins control many cellular processes via protein interactions. Drosophila Wuho (Wh, a WD40 protein) controls fertility, although the involved mechanisms are unclear. Here, we show that Wh promotion of Mei-p26 (a human TRIM32 ortholog) function maintains ovarian germ cell homeostasis. Wh and...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Rastegari, Elham, Kajal, Kreeti, Tan, Boon-Shing, Huang, Fu, Chen, Ruey-Hwa, Hsieh, Tao-Shieh, Hsu, Hwei-Jan
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
Assuntos:
Stem Cells and Regeneration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7375833/
https://ncbi.nlm.nih.gov/pubmed/31941704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.182063
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