HIF-2α is indispensable for regulatory T cell function

Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that regulate cellular responses to hypoxia, but the exact function in regulatory T (Treg) cells is controversial. Here, we show that Treg cell development is normal in mice with Foxp3-specific knockout (KO) of HIF-1α o...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hsu, Tzu-Sheng, Lin, Yen-Lin, Wang, Yu-An, Mo, Shu-Ting, Chi, Po-Yu, Lai, Alan Chuan-Ying, Pan, Hsuan-Yin, Chang, Ya-Jen, Lai, Ming-Zong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538433/
https://ncbi.nlm.nih.gov/pubmed/33024109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18731-y
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