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Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression
Death-associated protein kinase (DAPK) is a tumour suppressor. Here we show that DAPK also inhibits T helper 17 (Th17) and prevents Th17-mediated pathology in a mouse model of autoimmunity. We demonstrate that DAPK specifically downregulates hypoxia-inducible factor 1α (HIF-1α). In contrast to the p...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4915028/ https://ncbi.nlm.nih.gov/pubmed/27312851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11904 |
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