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Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice
Humanized mice expressing Human Leukocyte Antigen (HLA) class I or II transgenes have been generated, but the role of class I vs class II on human T and B cell reconstitution and function has not been investigated in detail. Herein we show that NRG (NOD.RagKO.IL2RγcKO) mice expressing HLA-DR4 molecu...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914985/ https://ncbi.nlm.nih.gov/pubmed/27323875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28093 |
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