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Long-term silencing of autoimmune diabetes and improved life expectancy by a soluble pHLA-DR4 chimera in a newly-humanized NOD/DR4/B7 mouse

Several human MHC class II (HLA) molecules are strongly associated with high incidence of autoimmune diseases including type 1 diabetes (T1D). The HLA-humanized mice may thus represent valuable tools to test HLA-based vaccines and therapeutics for human autoimmune diseases. Herein, we have tested th...

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Bibliografski detalji
Glavni autori: Pow Sang, Luis, Majji, Sai, Casares, Sofia, Brumeanu, Teodor D
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130268/
https://ncbi.nlm.nih.gov/pubmed/24335553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.27374
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