The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections

We have engineered a Human Immune System (HIS)-reconstituted mouse strain (DRAGA mouse: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD) in which the murine immune system has been replaced by a long-term, functional HIS via infusion of CD34(+) hematopoietic stem cells (HSC) from cord blood. Herein, we rep...

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Detalles Bibliográficos
Publicado en:Hum Vaccin Immunother
Main Authors: Mendoza, Mirian, Gunasekera, Devi, Pratt, Kathleen P., Qiu, Qi, Casares, Sofia, Brumeanu, Teodor-D.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2020
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553695/
https://ncbi.nlm.nih.gov/pubmed/32129705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2020.1713605
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