A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19

We report the first Human Immune System (HIS)-humanized mouse model (“DRAGA”: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19 research. This mouse is reconstituted with human cord blood-derived, HLA-matched hematopoietic stem cells. It engrafts human epi/endothelial cells expressing the human ACE2...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Brumeanu, Teodor-D., Vir, Pooja, Karim, Ahmad Faisal, Kar, Swagata, Benetiene, Dalia, Lok, Megan, Greenhouse, Jack, Putmon-Taylor, Tammy, Kitajewski, Christopher, Chung, Kevin K., Pratt, Kathleen P., Casares, Sofia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7444284/
https://ncbi.nlm.nih.gov/pubmed/32839773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.19.251249
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