Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice

Humanized mice expressing Human Leukocyte Antigen (HLA) class I or II transgenes have been generated, but the role of class I vs class II on human T and B cell reconstitution and function has not been investigated in detail. Herein we show that NRG (NOD.RagKO.IL2RγcKO) mice expressing HLA-DR4 molecu...

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Publicado no:Sci Rep
Main Authors: Majji, Sai, Wijayalath, Wathsala, Shashikumar, Soumya, Pow-Sang, Luis, Villasante, Eileen, Brumeanu, Teodor D., Casares, Sofia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914985/
https://ncbi.nlm.nih.gov/pubmed/27323875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28093
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