Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

BACKGROUND: Human-immune-system humanized mouse models can bridge the gap between humans and conventional mice for testing human vaccines. The HLA-expressing humanized DRAGA (HLA-A2.HLA-DR4.Rag1KO.IL2RγcKO.NOD) mice reconstitute a functional human-immune-system and sustain the complete life cycle of...

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Détails bibliographiques
Publié dans:Malar J
Auteurs principaux: Majji, Sai, Wijayalath, Wathsala, Shashikumar, Soumya, Brumeanu, Teodor D., Casares, Sofia
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853061/
https://ncbi.nlm.nih.gov/pubmed/29540197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-018-2264-y
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