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Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts

Doxorubicin (DOX) induces dose-dependent cardiotoxicity in part due to its ability to induce oxidative stress. We showed that loss of multidrug resistance-associated protein 1 (Abcc1/Mrp1) potentiates DOX-induced cardiac dysfunction in mice in vivo. Here, we characterized DOX toxicity in cultured ca...

詳細記述

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書誌詳細
出版年:Toxicol Sci
主要な著者: Zhang, Wei, St Clair, Daret, Butterfield, Allan, Vore, Mary
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914793/
https://ncbi.nlm.nih.gov/pubmed/26822305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw021
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