Loss of Multidrug Resistance–Associated Protein 1 Potentiates Chronic Doxorubicin-Induced Cardiac Dysfunction in Mice

Doxorubicin (DOX), an effective cancer chemotherapeutic agent, induces dose-dependent cardiotoxicity, in part due to its ability to cause oxidative stress. We investigated the role of multidrug resistance–associated protein 1 (Mrp1/Abcc1) in DOX-induced cardiotoxicity in C57BL wild-type (WT) mice an...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Zhang, Wei, Deng, Jun, Sunkara, Manjula, Morris, Andrew J., Wang, Chi, St. Clair, Daret, Vore, Mary
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2015
Schlagworte:
Toxicology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613956/
https://ncbi.nlm.nih.gov/pubmed/26354995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.225581
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