The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal

Doxorubicin (DOX)-induced acute cardiotoxicity is associated with the Gly671Val (G671V; rs45511401) variant of multidrug resistance-associated protein 1 (MRP1) (Circulation 2005; 112:3754). Redox cycling of DOX causes lipid peroxidation and generation of the reactive electrophile 4-hydroxy-2-trans-n...

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Main Authors: Jungsuwadee, Paiboon, Zhao, Tianyong, Stolarczyk, Elzbieta I., Paumi, Christian M., Butterfield, D. Allan, St.Clair, Daret K., Vore, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308135/
https://ncbi.nlm.nih.gov/pubmed/22293538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328350e270
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