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The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal
Doxorubicin (DOX)-induced acute cardiotoxicity is associated with the Gly671Val (G671V; rs45511401) variant of multidrug resistance-associated protein 1 (MRP1) (Circulation 2005; 112:3754). Redox cycling of DOX causes lipid peroxidation and generation of the reactive electrophile 4-hydroxy-2-trans-n...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308135/ https://ncbi.nlm.nih.gov/pubmed/22293538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328350e270 |
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